Direct from imaging

Determine the vulnerability of ascending aortic aneurysms to dissection, rupture and sudden death.

Patient-specific. Data driven. AI powered.

Why Aortico?

Aortic size tells only
part of the story.

Patients with similar aortic dimensions may have different geometries, mechanical properties, and patterns of vulnerability.

Aortico is being developed to provide this additional patient-specific context by combining medical imaging, biomechanics, and data-driven analysis.

Similar diameter. Different biomechanical vulnerability.

Patient A with a 46 mm ascending aortic diameter, BVI of 0.32, and low risk label

Patient B with a 46 mm ascending aortic diameter, BVI of 0.78, and high risk label

Biomechanical Vulnerability Index

A continuous view of
aortic vulnerability.

BVI summarizes the patient-specific biomechanical profile of the ascending aorta on a continuous scale from 0 to 1.

Higher values represent a more vulnerable biomechanical profile, not a direct probability of dissection.

Research-stage metric. Not currently intended as a clinical diagnosis.

BVI 0.00

Aneurysmal aorta at the lower end of the biomechanical vulnerability spectrum

Aneurysmal aorta with localized wall change at the midpoint of the biomechanical vulnerability spectrum

Aneurysmal aorta with a dissection-like tear at the higher end of the biomechanical vulnerability spectrum

Lower end of the biomechanical vulnerability spectrum.

Click or drag on the spectrum to explore the BVI scale.

Today's surveillance pathway

Illustrative

Dissection can occur here — below the size threshold

Serial imaging

Consider surgical repair

Diameter remains central to care, but guidelines also consider growth rate, body size, genetics, family history, and multidisciplinary clinical judgment.

How it works

One scan. Four steps. One patient-specific biomechanical profile.

Aortico transforms cardiovascular MRI into a patient-specific biomechanical characterization and summarizes the findings in an interpretable research report.

Anatomy

Build a patient-specific representation of the thoracic aorta from cardiovascular imaging.

Deformability

Characterize how the thoracic aorta changes throughout the cardiac cycle.

Flow characterization

Characterize patient-specific blood-flow behavior throughout the thoracic aorta.

Research report

Bring imaging-derived findings together in a clear, patient-specific research report.

Patient-specific aortic analysis. Explore the complete Aortico software workflow from medical imaging to geometric measurements.

Captured by imaging — area and flow across the cardiac cycle, from a routine MRI.

Validated on tissue — aortic tissue under biaxial load, taken to failure.

Clinical vision

Where this could change the pathway.

Clinic volumes keep growing while the surveillance model still treats every patient the same. These are the settings we are building toward.

Surveillance clinics

Separate the patients who need close watching from those who don't.

Pre-surgical evaluation

A second signal alongside size thresholds when timing an operation.

Research collaboration

A quantitative endpoint for studying how aortic disease progresses.

Research

Grounded in tissue.
Translated to imaging.

Aortico is built on a biomechanical dataset of more than 600 human aortic tissue specimens. These measurements provide a reference for understanding how the mechanical behavior of healthy, aneurysmal, and dissected aortas differs—and support the development of imaging-derived markers of aortic vulnerability.

0.92

AI-enabled classifier

0.92 AUC

The investigational biomechanical model achieved an AUC of 0.92 in distinguishing healthy donor and dissection tissue.

600+

The largest available aortic tissue dataset

600+ specimens

A large ex-vivo biomechanical dataset spanning healthy, aneurysmal, and dissected aortic tissue.

By linking tissue-level mechanical behavior with non-invasive cardiovascular imaging, Aortico aims to identify vulnerability patterns that are not captured by aortic diameter alone.

Tissue behavior in motion

Biaxial testing

Delamination testing

Bulge testing

The clinical question

Could mechanics reveal what diameter misses?

These are the outcomes Aortico is being developed to investigate with clinical partners.

Stratify

Identify which patients may warrant closer surveillance—and which may not.

Inform

Add a patient-specific biomechanical signal to multidisciplinary review.

Measure

Create a quantitative endpoint for longitudinal and interventional studies.

Our approach

Built to look past diameter.

Today's tools

–Measure size, or fragility — rarely both
–Population thresholds, not individual risk
–Often limited to one aortic segment
–Tissue testing requires tissue

          Aortico
          Characterizes vulnerability, not just size
Imaging joined to tissue-validated biomechanics
Covers the thoracic aorta end to end
Non-invasive, from scans already collected

        